Duphaston and pregnancy planning: we take the drug correctly. Contraindications and side effects

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08.02.2021

Duphaston is a hormonal pill that women take if they have problems in the reproductive system. The drug is a synthetic analogue of progesterone. It should be drunk only after confirmation by the doctor of hormone deficiency. Self-medication can adversely affect a woman's health and only aggravate her illness.

Reception features

Sometimes girls take medicine according to the schemes written on the forums, or do not adhere to the rules at all. They may miss taking Duphaston one or more times, which is why they will not achieve the effect at all.

Today, various variations of treatment courses are described in the instructions for the drug. However, if you drink pills exactly according to these schemes, there is no guarantee of success. For each patient, the doctor individually describes the cycle of therapy. And he tells the woman what to do after missing Duphaston.

Approximate schemes for the use of tablets depend on the diagnosis and are as follows:

  • For endometriosis treatment drink one tablet three times a day, starting from the 5th day of the cycle to the 25th.
  • Infertility treatment continue from 3 months to six months. Drink one capsule twice a day. The dose may vary depending on the degree of hormonal deficiency.
  • Supportive care during pregnancy, it is carried out in the same dosages as before its onset. However, if you skip a Duphaston tablet, the risk of fetal rejection increases.
  • If a woman has threatened abortion, then you should take 4 tablets once. After 8 hours, another dose is taken, after which they continue to drink one tablet per day for a week.
  • When staging a habitual abortion(several miscarriages in a row), a woman is prescribed one tablet per day from 11 to 25 days of the menstrual cycle 3-6 months before pregnancy.
  • To equalize menstruation the patient is prescribed 2 capsules a day in the morning and evening in the second phase of the cycle (from 11 to 25 days) for several months.

Skipping a tablet during any of the above regimens may not have any consequences, and may lead to unexpected reactions. Therefore, Duphaston should be used carefully, strictly adhering to the course.

What to do after a missed appointment

There are many cases and unforeseen situations due to which you can forget to take Duphaston. Hormonal drugs are drunk on certain days, and some even at a set time. Usually, skipping at least one dose does not affect a woman’s health very well, but in the case of Duphaston, everything is not so scary.

The patient, if she missed a Duphaston tablet, should drink it within 6 hours. In this case, there will be no consequences.


Delaying more than 6 hours may adversely affect reproductive function. However, it is no longer necessary to take the medicine, and the course should be continued according to the scheme prescribed by the doctor.

Missing Duphaston during pregnancy increases the risk of spontaneous abortion. Especially if this happened in the first few weeks of the term in girls prone to miscarriages. A woman should set herself reminders to take pills so as not to undermine the health of her baby.

Consequences of skipping

It is strictly forbidden to abruptly stop taking Duphaston. The female body, due to the abrupt cessation of hormone intake, reacts inadequately. Therefore, if a girl missed taking Duphaston, she may be disturbed by:
  • sudden uterine bleeding;
  • heavy menstruation, uncharacteristic for the phase of the cycle;
  • retention of secretions;
  • occurrence of side effects drug.
As a rule, these conditions are eliminated by themselves if you continue to drink the medicine without gaps. And in order to take Duphaston during pregnancy and before it as safe as possible, you should carefully adhere to the developed scheme.

The drug Duphaston is prescribed to pregnant women with a threat of miscarriage. The composition of the product includes a hormone that improves the condition during pregnancy and normalizes the hormonal background of the expectant mother. It is also prescribed for endometriosis. The drug is safe in the first months after conception.

Description of the drug

The drug is available in the form of round tablets of 10 mg with dydrogesterone. Duphaston's main active ingredient is an artificial substitute for progesterone (pregnancy hormone). During pregnancy, it is normally produced independently by the female body: it is responsible for the life of the fetus and its intrauterine development. In some diseases, the hormone is not produced after conception, therefore, treatment with the described hormonal drug is prescribed.

The molecular structure of dydrogesterone is similar to the natural hormone. An artificial analogue has a pronounced effect on internal organs. Dydrogesterone is a safe synthetic structure, therefore it does not affect blood clotting and carbohydrate synthesis in the liver.

Duphaston is prescribed for any condition that is accompanied by a lack of progesterone. The main diseases for which the drug is prescribed:

  1. Infertility caused by luteal deficiency is accompanied by a violation of the production of progesterone and a change in the uterine mucosa.
  2. Endometriosis - benign formations on the walls of the uterus and beyond. The disease occurs against the background of anemia and hormonal failure, sometimes it causes infertility if a cyst forms on the ovary.
  3. Cyclic syndrome - manifests itself 7 days before menstruation, accompanied by vegetovascular and endocrine disorders.
  4. The risk of miscarriage - creates the possibility of spontaneous abortion due to uterine hypertonicity. This phenomenon is directly related to the hormone progesterone, which during pregnancy relaxes muscle tone, thereby reducing the risk of spontaneous miscarriage.
  5. Violation of the menstrual cycle - occurs due to hormonal disruptions, stress and difficult experiences.
  6. Secondary amenorrhea is the cessation of menstruation for more than 6 months. It is observed in young women capable of conception.
  7. Abundant uterine bleeding - appear against the background of an imbalance or dysfunction of the ovaries, in this case, hormonal treatment is prescribed.

The drug Duphaston is also used for menopause.

The action of the hormone

The hormone "pregnancy" (progesterone) in the normal state is formed in the ovaries from 12 to 23 days of the cycle. If conception does not occur, its amount in the blood gradually decreases, and during the fertilization of the egg, on the contrary, it increases.

Also, the natural hormone is responsible for the accumulation of adipose tissue in the body of a woman and the relaxation of the smooth muscles of the gastrointestinal tract. The lack of a substance affects the whole body - a woman feels weakness and lethargy.

The most active hormone progesterone begins to work immediately after the fertilization of the egg. And it is thanks to him that the mucous membrane of the uterus is prepared for the implantation of the fetal egg. Also, progesterone is involved in preparing the body for childbirth, affects breast growth in the second trimester of pregnancy, and relaxes muscles throughout the body. If its concentration in the blood falls, the probability of a miscarriage is high.

Duphaston is prescribed for early dates pregnancy

To eliminate the lack of female progesterone, Duphaston is prescribed in the early stages of pregnancy. Dydrogesterone restores hormonal levels, maintains pregnancy and reduces muscle tension. It has been clinically proven that Duphaston does not affect the development of the fetus.

The medicine is prescribed only after a blood test: this is how the level of progesterone is determined.

Advantages of Duphaston

The main advantages of the drug:

  • does not cause severe consequences after administration;
  • begins to act after two hours, does not affect the stomach and intestines;
  • does not provoke a change in the menstrual cycle, does not affect ovulation;
  • reduces uterine contractions, relaxes spasms, contributes to the life support of the fetus;
  • reduces the growth of cellular structures, thereby treating endometriosis;
  • used to relieve various hormonal diseases;
  • does not cause pathologies in the development of the fetus, it acts safely throughout the entire period of pregnancy.

Prescribing a drug

The drug is prescribed after determining the concentration of progesterone in the blood. The main cases when Duphaston is prescribed:

  • risk of spontaneous abortion of a pregnant woman: characterized by complications in the first weeks after conception. At this stage, the main functions and systems of the baby are formed, organs are laid and the placenta is formed. If there is a risk of miscarriage, treatment is prescribed. The dosage is determined individually, taking into account the existing disease and the magnitude of the risk of spontaneous abortion.
  • history of miscarriages: if a woman has repeated miscarriages, then she is prescribed a drug in advance. Usually, it is started at the time when the likelihood of a miscarriage is highest. With habitual miscarriage, Duphaston is prescribed immediately after conception;
  • preparation for IVF: the preparation prepares the lining of the uterus for the acceptance of the embryo. When infertility is diagnosed, ovarian dysfunction is often observed, so the level of progesterone decreases, and this increases the risk of rejection of the fetus during its transfer. Preparation for transplantation of the fetal egg includes taking Duphaston 20 days before embryo transfer and for 22 weeks after;
  • conception planning: the agent is used at 10 mg from the 13th to the 25th day of the cycle. Treatment is prescribed by the course.

The dosage is determined only by the attending physician based on the results of the studies. The effect of the drug must be monitored by a gynecologist. If you experience side effects, you should inform your doctor about it and follow his recommendations.


It is not recommended to stop taking Duphaston on your own - it is dangerous for the child

If one dose is missed, the medicine should be taken within six hours, without exceeding the prescribed dosage.

Duphaston in the first trimester of pregnancy

In the first months, Duphaston is prescribed by a gynecologist. It is prescribed to women who are in a certain risk zone. If abortions were performed, there were miscarriages, there are diseases of the genitourinary system, then Duphaston is prescribed to eliminate adverse risks in the early stages of fetal development.

The course of treatment is prescribed for the period of formation of the placenta - from 2 to 16 weeks of pregnancy. During this period of time, the likelihood of a miscarriage increases if the body does not produce progesterone on its own.

A common reason why expectant mother Duphaston is prescribed - this is uterine hypertonicity. This disease is characterized by high muscle tension, which is often the cause of spontaneous miscarriage. Increased tone speaks of a low level of progesterone, which prepares the mucous surface of the uterus for the adoption of the fetal egg and reduces muscle tension. The replacement in this case is dydrogisterone, which is part of Duphaston.

Symptoms to look out for

In the first weeks after conception, some women experience certain symptoms that indicate an unfavorable course of pregnancy and serve as a reason for drug treatment. They mean:

  1. Painful sensations in the abdomen - pulling, aching pains in the center and below the navel appear in the first weeks of pregnancy with the threat of miscarriage. However, if tingling pains appear on the side, then this indicates the preparation of the uterus for bearing the fetus.
  2. Bloody discharge from the genital tract - at any stage of pregnancy is a clear symptom of a possible miscarriage. Even a small amount of discharge indicates an imbalance. Often the cause is the detachment of the fetal egg (in the first weeks of the term) or the placenta (in the second half of pregnancy) from the walls of the uterus. In this case, oxygen starvation develops, the fetus does not receive nutrients and may die.
  3. Muscle tone: manifested with a lack of hormones, emotional stress, diseases of the genital organs. You can diagnose muscle hypertonicity on your own only by feeling discomfort in the groin, a feeling of tension. The disease is diagnosed by ultrasound during the first weeks of pregnancy: the back and front walls of the uterus are tense and cause muscle spasms.

Before treating all of the above symptoms, a general examination is prescribed, which includes:

  • general analysis of blood, urine;
  • biochemical test;
  • checking the microflora of the cervical canal;
  • determining the tolerance of hormonal drugs;
  • urinalysis for the amount of hCG ( chorionic gonadotropin person) - in the first trimester;
  • conducting an ultrasound examination;
  • examination by a gynecologist.

Based on the analyzes obtained, a competent treatment with a hormonal agent is compiled.

How to use

During pregnancy, the drug is prescribed by a doctor, he selects the dosage taking into account the individual characteristics of the body, as well as the symptoms of the disease. If the remedy was taken before conception, then it should be continued in the same amounts in the first weeks after conception. As soon as the placenta is fully formed, the drug is gradually canceled.

Duphaston is often prescribed 1 tablet 2-3 times a day. The duration of treatment in most cases is limited to the sixteenth week of pregnancy - at this time the placenta is already fully formed and there is no need for the drug. Sometimes Duphaston is prescribed up to 23 weeks to eliminate the possibility of a miscarriage.


Duphaston can only be used as directed by a doctor.

For each disease, their standard dosages are prescribed (adjusted by the doctor individually):

  • infertility: one tablet a day from the fourteenth to the twenty-fifth day of the cycle. Treatment is carried out in courses for six months;
  • the likelihood of abortion: two tablets at once, then one every seven hours until the risk is eliminated;
  • dysmenorrhea: several times a day, 10 mg from the fifth to the twenty-fifth day of the cycle;
  • amenorrhea: 10 mg several times in 24 hours in the second phase of the cycle;
  • bleeding from the genital tract after conception: several times a day, 10 mg for seven days. To prevent open bleeding in the future - 10 mg daily in the second part of the cycle.

When using the medicine, planned medical examinations are mandatory.

Contraindications and side effects

The hormonal remedy Duphaston can be used during pregnancy, as it does not negative impact to the fruit. However, this does not mean that the drug does not have side effects. So, its use is fraught with:

  • vomiting;
  • headaches;
  • open bleeding;
  • clouding of consciousness;
  • allergic reactions.

Each organism reacts to the drug in its own way, so in the first days of taking the pills, you should carefully monitor your well-being.

Duphaston should be used carefully when taking contraceptives for a long time. The combination of estrogen and progesterone is fraught with the formation of blood clots. If drugs are taken at the same time, then you should carefully study the contraindications of estrogenic drugs, and also ask your doctor for the exact dosage.

Duphaston contraindications:

  • hepatic diseases;
  • hereditary Dubin-Johnson and Rotor syndromes;
  • allergy to the components of the drug;
  • pathological formations in the chest, cysts of the genital organs;
  • tendency to thrombosis.

When taking the drug, bleeding may occur. They must be prevented with a double dose.

In the presence of a tumor, as well as its progressive growth during pregnancy, the dosage is prescribed by the doctor, and the treatment is carried out strictly under his supervision.


Hormonal medications should be taken with caution

Rare side effects of the drug:

  • reactions of the circulatory system: hemolytic anemia;
  • reflection on the central nervous system: migraine, pain attacks;
  • effects on internal organs: malfunctioning of the liver, manifestation of fatigue, jaundice, pulling discomfort in the lower abdomen;
  • reactions of the genitourinary system, genital organs: the occurrence of open bleeding, pain and sensitive mammary glands;
  • skin reactions: rash, rubella, itching, less often Quincke's edema;
  • common pathologies: swelling of the peripheral type.

How to cancel Duphaston

Reduce the intake of Duphaston should be gradual. It is impossible to abruptly cancel the drug. In a standard situation, the medicine is taken until the 15-19th week of pregnancy. Doses at the same time comply with those prescribed by the doctor. At the end of the course of treatment, it is necessary to reduce the amount by half a tablet in seven days. At the same time, it is allowed to start reducing the dosage of Duphaston only after the restoration of the hormonal background.

It is important to understand that you need to use Duphaston according to the instructions and strictly following the dose that the doctor has determined. Self-medication with the drug, as well as prevention with its help, is contraindicated, since dydrogisterone has a number of side effects: it affects the functions of the heart and liver, worsens work internal organs. It should be used with caution when kidney failure if you have diabetes mellitus, as well as with a predisposition to allergies.

However, the drug does not affect the composition of the blood, maintains blood pressure at the same level and does not affect the metabolism. The main thing that is necessary for Duphaston therapy to provide the desired results is a doctor's consultation and the correct dosage.

Quite often, a person finds himself in situations where he needs to take certain medicines. Hormonal drugs in most cases are prescribed to the fairer sex. It is their body that undergoes cyclical changes every month. One of the most popular drugs prescribed is artificial progesterone. It is worth considering in detail how to take Duphaston.

How does the female body work?

Every month a woman begins a new cycle. It consists of two phases: the first and the second. Divides the cycle into parts the day when the egg is released from the ovary.

In the first part of the month, the woman's body secretes hormones that are necessary for the proper growth of the egg and the preparation of the uterine layer for pregnancy.

The second phase is called the luteal. During it, there is a strong release of the hormone progesterone. It is he who is responsible for the normal course of pregnancy in case of fertilization. The drug "Duphaston" is an artificial substitute for progesterone.

When is this drug prescribed?

Tablets "Dufaston" the doctor prescribes only after a preliminary examination. It can be recommended to a woman in the following cases:


It is worth noting that it is always necessary to comply with the prescribed dosage and time of treatment.

How to take "Dufaston"?

Depending on the diagnosis made to the woman and what is the cause of the disease, an individual dose of the drug is selected. Also, the dosage and time of taking the drug may be different. Consider how to properly take "Dufaston" for a particular disease.

During the threat of spontaneous miscarriage

If a pregnant woman has a threat of termination of pregnancy, then in most cases she is prescribed this remedy. How to take "Dufaston" in this case, the doctor decides. It all depends on the severity of the symptoms and the cause of their appearance.

In most cases, the patient is prescribed a single dose of four tablets, which is forty milligrams of the drug. Thereafter, it is recommended to consume one capsule every eight hours. This must be done until the symptoms disappear completely: pain, bleeding, feeling unwell.

If a woman has a threat of miscarriage due to a lack of progesterone in the body, then how to drink the medicine in this case? Usually the doctor prescribes two tablets per day, which must be taken at regular intervals. It should be noted that in such a situation, the time of treatment with the drug "Dufaston" is significantly increased. How long can you take it, the specialist will tell. In most cases, such treatment is prescribed before the start of the second trimester of pregnancy, when the placenta completely takes over the production of the necessary hormone.

Duphaston tablets for infertility: how to take?

Quite often, this drug is prescribed to women planning a pregnancy. If the fair sex has a regular sex life without the use of contraceptives, but conception does not occur, then she should consult a doctor. The first symptom of insufficiency of the second phase is its short length. After analyzing for the necessary hormone, the doctor may recommend its additional intake.

So, how to take "Duphaston" to get pregnant? In most cases, the medication is prescribed one tablet per day. It is necessary to drink them from the 14th day after the start of the last menstruation and up to the 25th day. However, with this appointment, it is worth remembering that this scheme is only suitable for women with a regular cycle of 28 days. If you have a longer cycle, then you can use additional progesterone only after ovulation. Otherwise, you can achieve the opposite contraceptive effect. Taking the drug "Duphaston" before the release of the egg from the ovary can simply suppress it.

With hormonal diseases

Very often, with various pathologies associated with improper production of hormones, progesterone is prescribed. One treatment option may be to prescribe Duphaston tablets for endometriosis. How to take the medicine in this case depends on the severity of the symptoms of the disease and the stage of the disease.

As a rule, doctors adhere to the following scheme. The patient is prescribed medication one capsule two to three times a day. The duration of treatment is 11 days: from the 14th day from the beginning of the last menstruation to the 25th.

At a more serious stage of the disease, the doctor may prescribe a continuous dose of the drug. In this case, a woman needs to take one pill twice a day. Reception should be carried out at regular intervals. Only in this case it is possible to achieve the maximum effect of the treatment.

With violations of the female cycle

If the fair sex has irregular periods, then she may also be prescribed an additional dose of progesterone. In the case of severe premenstrual syndrome, the doctor may recommend the use of Duphaston tablets.

In these cases, the drug is prescribed from the 11th day from the beginning of the last menstruation. The course of taking the drug should continue until the 25th day of the cycle. It is necessary to take the medicine one tablet 2 times a day at regular intervals.

Prolonged absence of menstruation (amenorrhea)

How to take Duphaston if a woman does not have periods, but this is not related to pregnancy? In this case, the use of this medication is prescribed from 11 to 25 days of the cycle. Be sure to supplement the treatment with drugs containing estrogen.

For bleeding of unknown origin

To stop bleeding, the drug "Dufaston" is prescribed for one week. It must be taken twice a day, one capsule. Before prescribing the drug, it is necessary to establish the cause of such secretions.

To prevent dysfunctional bleeding, one capsule is prescribed twice a day during the menstrual cycle - from 11 to 25 days.

With hormone replacement therapy (after removal of the ovaries)

If a scheme is chosen in combination with estrogens, then in the first two weeks one drug is prescribed. In the next two weeks, it is necessary to use Duphaston tablets.

If the intake of estrogen is contraindicated, then only artificial progesterone is prescribed for two weeks, after which it is necessary to take a break for 10-15 days.

The dosage of the drug in these cases is 10 mg, that is, one capsule per day.

With tumor processes in the female body

If a woman has cysts on the ovaries or other organs, then how to drink the drug "Dufaston" in this case?

If the tumor is estrogen-dependent, which happens most often, then the medicine is prescribed two tablets per day throughout the entire cycle. The goal of treatment in this case is to suppress estrogen production.

Proper selection of the dosage of the drug

Usually this medicine is produced in the following form: in a cardboard box, a plate with 20 tablets. One pill contains 10 milligrams of the drug. But in some cases, you can find a higher dosage - 20 milligrams. You should always pay attention to this, since in this case it is necessary to drink Duphaston tablets according to a different scheme.

Conclusion

If you are prescribed the drug "Dufaston", then you must adhere to the selected course of treatment. In each case, the regimen for the use of the drug should be individual. Otherwise, you will not get an effective result from the hormonal treatment performed.

Before prescribing the drug, a preliminary examination should always be carried out. It is also necessary to take into account the duration of the female cycle.

Monitor the state of your hormones and carry out the necessary treatment in time. Be healthy!

Duphaston is a synthetic hormonal drug of the latest generation, which is an artificial analogue of the female hormone progesterone.

The unique feature of the drug lies in its chemical formula, which is almost identical to the structure of the natural hormone progesterone. It is necessary for the female body to ensure biological changes associated with the preparation for pregnancy and its normal course. The basis of the drug is the progestogen hormone - dydrogesterone. It acts directly on the uterine mucosa, which eliminates most of the side effects that accompany the use of other synthetic hormones.

On this page you will find all the information about Duphaston: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Duphaston. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

The active ingredient of the drug dydrogesterone is an analogue of natural progesterone. Dufaston is a hormonal drug.

Terms of dispensing from pharmacies

Released by prescription.

Prices

How much does Duphaston cost? The average price in pharmacies is at the level of 480 rubles.

Release form and composition

Coated tablets, 10mg. 20 tablets in PVC/Al blister. 1 PVC / Al blister, together with instructions for use, is placed in a cardboard box.

  • 1 coated tablet contains: active substance: dydrogesterone, 10 mg;
  • Excipients: lactose monohydrate, hypromellose, corn starch, colloidal silicon dioxide, magnesium stearate;
  • Sheath: Opadry white Y-1-7000 (hypromellose, polyethylene glycol 400, titanium dioxide (El 71)).

Round, biconvex, white, film-coated, beveled-edged tablet, scored on one side, engraved with an "S" above the "T" sign on one side of the tablet and "155" on the other side (on both sides of the notch).

Pharmacological effect

In terms of its molecular structure, pharmacological and chemical properties, dydrogesterone is close to natural progesterone. This element is not a derivative of testosterone, does not have side effects that are inherent in almost all synthetic progestogens, which are also called androgenic progestogens. Dydrogetestrone has no glucocorticoid, anabolic, androgenic, estrogenic, or thermogenic activity.

Duphaston according to the instructions is part of a complex HRT for menopause, the drug retains a beneficial effect on the blood lipid profile from estrogens. Unlike the estrogen hormones, which negatively affect the blood coagulation system, didrogestrone has no effect on the coagulation index. According to the instructions, the drug does not have a negative effect on the liver, carbohydrate metabolism when planning the conception.

When taken orally, dydrogesterone selectively acts on the endometrium, which helps prevent an increased risk of hyperplasia or carcinogenesis due to excess estrogen. The medication according to the instructions is indicated for endogenous progesterone deficiency. Dufaston does not have a contraceptive effect, because it is used when planning a pregnancy. The tool makes conception possible, ensures the preservation of pregnancy during therapy.

Indications for use

The use of Duphaston is indicated in cases where there is or is suspected a deficiency of endogenous progesterone, in cases where its positive effect has been clinically proven:

  • infertility due to luteal insufficiency;
  • threatened abortion;
  • habitual abortion;
  • premenstrual syndrome;
  • dysmenorrhea;
  • irregular cycle.

In addition, in combination with estrogen, Duphaston can be used for:

  • secondary amenorrhea;
  • dysfunctional uterine bleeding.

Contraindications

You can not take medication:

  1. Lactase deficiency, galactose and glucose intolerance, malabsorption syndrome;
  2. The period of breastfeeding;
  3. Hypersensitivity to the components of the drug.

If the patient's history indicates itching during a previous pregnancy, Duphaston should be used with caution.

Use during pregnancy and lactation

According to the instructions, Duphaston is used during pregnancy according to indications.

Since dydrogesterone can be secreted from breast milk, if necessary, treatment with the drug is recommended to stop breastfeeding.

Instructions for use

The instructions for use indicate that Duphaston tablets are taken orally. The dosage of the drug should correspond to the diagnosis. Treatment is carried out only on prescription and under medical supervision.

  1. Infertility caused by luteal insufficiency- appoint 1 tablet per day from the 14th to the 25th day of the cycle. The drug is taken for at least six months or 6 cycles. If conception has already occurred, then Duphaston should be taken further, as with a threat of abortion.
  2. Endometriosis - dosage of 10 mg (1 tablet) 2 to 3 times a day. They start either from the 5th to the 25th day of the monthly cycle, or a permanent intake.
  3. Habitual abortion - take 1 tablet 2 times a day. Treatment should be continued until the 20th week of pregnancy, then the dosage is gradually reduced.
  4. Threatened abortion- take 40 mg (4 tablets) once. Then 1 tablet every 8 hours until the situation returns to normal. If the symptoms begin to increase again, then the dose of the drug should be increased again. Further, "Dufaston" should be taken until the 12-20th week of pregnancy.
  5. Prolonged absence of menstruation (amenorrhea)- complex treatment - estrogen-containing drugs, 1 tablet per day, starting from the 1st day of the cycle. From the 11th day of the cycle, treatment is supplemented with Duphaston. These drugs should be taken until the 25th day of the cycle. Application is designed for at least 3 menstrual cycles.
  6. Painful menstruation- 1 tablet 2 times a day. Application is indicated from the 5th to the 25th day of the cycle.
  7. PMS - is prescribed 1 tablet 2 times a day. Treatment is carried out from the 11th to the 25th day of the cycle. The drug is prescribed for a period of 3 to 6 months.
  8. Irregular monthly cycle- the drug is prescribed for 1 table. 2 times a day. "Dufaston" should be used from the 11th to the 25th day of the cycle.
  9. Hormone Replacement Therapy- is prescribed in a pair with estrogens, 1 tablet 1 time per day for 2 weeks within a 28-day cycle. Usually the reception takes place in the last 14 days of the cycle. If the response to progesterone therapy is not detected by ultrasound and is not confirmed by tests, then the dose should be revised upwards.
  10. Dysfunctional uterine bleeding- the dose is 1 tab. 2 times a day. The duration of treatment is from 5 to 7 days. As a prophylaxis of bleeding, the use of the drug is prescribed - 1 table. 2 times a day. Therapy is carried out from the 11th to the 25th day of the cycle.

Side effects

When taking Dufaston, the development of adverse reactions is possible:

  1. The hematopoietic system may respond to the drug with symptoms of hemolytic anemia.
  2. From the side of the central nervous system, dizziness and headaches are possible.
  3. From the genital area, sometimes there are breakthrough uterine bleeding, sometimes there is pain and swelling of the mammary glands.
  4. On the part of the skin, allergic manifestations are possible in the form of urticaria, itching, skin rash. In very rare cases, there is a development of such complications as angioedema.
  5. In some cases, there is a problem with the liver, expressed in weakness and malaise, jaundice, some patients note that after Duphaston, the stomach hurts.

Uterine bleeding when taking the drug is easily stopped by increasing the dose of Duphaston. If adverse reactions occur, you should consult your doctor, you may need to adjust the dose, and in case of allergic reactions, stop the drug.

Overdose

There have been no reports of overdose symptoms. In case of accidental intake at a dose significantly higher than the therapeutic dose, gastric lavage is recommended. There is no specific antidote, treatment should be symptomatic.

special instructions

Currently, there are no data on the negative effect of dydrogesterone in chronic renal failure.

A thorough clinical examination is required if a history of a progesterone-dependent tumor (eg, meningioma) is indicated, as well as in case of its progression during pregnancy or during previous hormonal therapy.

In the case of prescribing dydrogesterone in combination with estrogens (for example, for hormone replacement therapy), contraindications and warnings associated with the use of estrogens should be taken into account.

Before starting hormone replacement therapy (HRT), a complete history should be taken. During treatment, it is recommended to periodically monitor the individual tolerance of HRT. The patient should be informed about any changes in the mammary glands she should report to the doctor. Investigations involving mammography should be performed in accordance with conventional patient screening.

Sometimes during the first months of treatment, breakthrough uterine bleeding may occur. If breakthrough bleeding occurs after a period of taking the drug or continues after a course of treatment, the cause should be investigated, an endometrial biopsy should be taken to exclude malignant changes in the endometrium.

Do not prescribe Duphaston tablets to patients with genetically determined galactose intolerance, lactase deficiency or malabsorption syndrome.

drug interaction

There may be some decrease in the effectiveness of Duphaston when taken in parallel with Rifampicin or Phenobarbital, which affect microsomal liver enzymes. These drugs are able to increase the rate of biological transformation of the hormonal drug Duphaston.

To date, there have been no reports of drug incompatibility of Duphaston with other drugs.

With the parallel appointment of a progestogen with estrogens, it is advisable to take into account the indications and contraindications for the latter.

Often, today, many women who want to become mothers face problems conceiving and bearing a baby, such problems can be identified among 16-20% of women who seek help from a doctor.

Today, there are schemes developed by gynecologists that involve taking duphaston, a drug that helps in the onset and maintenance of pregnancy.

Why is Duphaston prescribed during pregnancy

Duphaston is a medical preparation for oral administration in tablets. It has progestogenic activity against the uterine mucosa (it is an analogue of natural progesterone).

This drug is well perceived by the woman's body, without affecting the health of the liver, while it normalizes the state of the endometrium of the uterus, without disturbing the process of menstruation and ovulation.

This increases the chances of successful conception, reducing the risk of miscarriage and fading of pregnancy.

Duphaston, unlike its counterparts, does not have a sedative effect on nervous system, does not affect the tone of the uterus, and does not have anabolic, estrogenic and corticoid effects. When taken, it almost does not cause side effects and increases the resistance of nerve tissues to damaging factors.

Taking Duphaston during pregnancy

Duphaston is usually prescribed in the early stages of pregnancy, or even from the planning stage of pregnancy and continues to be taken from the moment of conception.

The appointment of the drug is made by a gynecologist, and in most cases the drug is indicated in order to maintain and safely prolong the pregnancy until the time when the functions of hormone synthesis will be taken over by the placenta.

By taking duphaston during pregnancy, the level of progesterone in the blood plasma is normalized, which contributes to the normal course of pregnancy.

Duphaston during pregnancy can also be used with the threat of its interruption, in order to prevent miscarriages during ICSI or IVF procedures, with previous abortions in the early stages or with a history of missed pregnancy.

If the drug is used as prescribed by a doctor, the question of whether it is possible to drink duphaston during pregnancy does not even arise - it is directly indicated.

How does it affect pregnancy

With many years of research on the drug, the positive aspects of taking duphaston during pregnancy are confirmed.

The drug used in the planning stage prepares the uterus and its inner layer for conception, and then helps in the successful conception, implantation and development of the fetus until the placenta finally develops and it takes over the functions of producing hormones.

When using dufaston, a significant decrease in the percentage of spontaneous abortion in the first weeks of pregnancy was revealed, as well as the risks of fetal malformations and various anomalies in the development of the placenta.

An additional supply of progesterone can help the area of ​​​​the future placenta in creating hormonal, nutritional and oxygen balance for the fetus.

Due to this, children born while taking dufaston at birth have normal weight, physical and psycho-emotional health.

Is Duphaston dangerous during pregnancy?

Any drugs can become dangerous with uncontrolled use or self-medication, which is also true for duphaston.

Specialists with systemic and proper administration call difaston a harmless and absolutely safe drug during pregnancy.

According to the statistics of taking the drug, for a long time of its use in obstetrics and gynecology, there has not been a single case of a harmful and negative effect of duphaston on the processes of conception or on the bearing of the fetus.

Moreover, sometimes without this drug, pregnancy will simply be at risk, and it is vital for the full development of the fetus in the first trimester.

Naturally, the drug should be taken under the supervision of a doctor and when determining the level of hormones in the woman's blood with its further correct cancellation in time.

Duphaston is taken orally, and when absorbed into the blood, it has a selective effect on the endometrium of the uterus, which helps to prevent its excessive growth or the degeneration of endometrial cells into malignant ones with an excess of estrogens in the body.

Duphaston has no contraceptive effects, it is unable to inhibit ovulation and disrupt menstrual functions, but it helps a lot during pregnancy.

The drug is very well and quickly absorbed from the intestine into the blood, reaching a maximum concentration in the blood in about two to three hours. The drug is metabolized in the liver, without harming its functions, and excreted by the kidneys for two days.

This allows you to maintain its stable concentration in the blood at the desired level throughout the course of treatment.

How to take Duphaston during pregnancy?

The doctor will develop the correct regimen for taking the drug, based on the problem that interferes with the normal onset or course of pregnancy.

If this is an overgrowth of endometrial tissue, it is usually prescribed in a tablet two to three times a day, with last day menstruation up to the 25th day of the cycle, or continuous use of the drug.

If this is a failure of the second phase of the cycle (luteal), the drug is prescribed from the day of ovulation to the 25th day of the cycle. Usually, in order to prepare for a successful pregnancy, the reception is carried out up to six months in a row, and when a successful conception occurs, it is also continuous throughout the first trimester of pregnancy.

If duphaston is used with the threat of spontaneous miscarriage, 4 tablets are usually prescribed immediately, and then one three times a day until the threat ceases.

How to drink duphaston during pregnancy - the doctor will write for you if it was prescribed before pregnancy, it is mandatory to take it up to 16 weeks of pregnancy.

The exact dose is determined by the doctor, based on the degree of threat and the level of progesterone in the blood of the pregnant woman.

If progesterone was not used before pregnancy, or there was a sharp decrease during pregnancy, the appointment of duphaston can be continued until 24-25 weeks of pregnancy at the discretion of the doctor.

The exact duration of treatment will be determined by the doctor, based on the results of the examination and examinations, your well-being.

The drug is usually used in the first trimester so that the fetus is successfully implanted and the placenta is formed.

But according to the indications, it is possible to use duphaston during the second trimester to prevent miscarriage, and sometimes the third. But after 36 weeks of pregnancy, the drug is always canceled.

If the drug is missed - what to do?

Of course, it is better not to skip taking the drug, but given its cumulative effects, this is not critical.

If one tablet is missed (forgotten, it was not possible), it is recommended to drink the next dose in the next 6 hours.

If more than six hours have passed, no additional dose is required, continue taking the drug as usual.

Try not to miss taking the drug, adhering to the same time. This will maintain optimal high concentrations of the substance in the blood plasma.

Cancellation of duphaston during pregnancy

The drug is canceled gradually, and the doctor will tell you how to reduce the dose of duphaston during pregnancy.

Usually, a gradual decrease in dosage of 0.5 tablets per week is carried out so that there is no sharp jump in hormonal levels and pregnancy failure.

For example, when taking two tablets per day, the dose is reduced to 1.5 tablets, and then a week later to one. Gradually reduce the dose to nothing.

Duphaston: side effects during pregnancy

Side effects as a result of taking duphaston are rare, and are usually easily corrected by changing the dose of the drug.

When taking the drug in small doses, there may be daubing and slight bleeding, which are eliminated when the dose is increased. The sensitivity of the mammary glands may increase, headaches or epigastric pains occur.

Rare may be skin rashes, swelling in the legs or arms, changing sexual desire (decrease or increase). In general, this is extremely rare, and the drug is well tolerated.

An overdose of the drug this moment was not recorded in the literature.

Can Duphaston terminate a pregnancy?

Duphaston is a synthetic analog of the corpus luteum hormone of pregnancy, it does not have contraceptive and abortive effects. It does not apply to the means of abortion.

It is designed, on the contrary, to help maintain pregnancy, and cope with the threats of its termination.

Contraindications for admission

The main contraindication to taking it is individual intolerance to the drug and allergic reactions to its intake.

Also, the drug is not prescribed for rare Rotor and Dubin-Jones syndromes, severe liver damage, malignant tumors of the breast and reproductive organs.

Very carefully prescribe the drug for thrombophlebitis and a tendency to thrombosis.